Mini P Sajan Selected Research

PKC-3 protein

3/2021	Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus.
1/2018	Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
1/2017	Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
11/2015	BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.
1/2015	Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
7/2014	Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
1/2014	Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.
11/2013	Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
6/2012	Atypical protein kinase C in cardiometabolic abnormalities.
6/2009	The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity.

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Mini P Sajan Research Topics

Disease

22	Insulin Resistance 01/2018 - 10/2002
14	Type 2 Diabetes Mellitus (MODY) 03/2021 - 02/2002
14	Obesity 03/2021 - 10/2002
12	Hyperinsulinism (Hyperinsulinemia) 03/2021 - 04/2006
8	Glucose Intolerance 01/2018 - 08/2003
8	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2014 - 01/2004
5	Hyperlipidemias (Hyperlipidemia) 03/2021 - 06/2009
3	Hypertriglyceridemia 06/2012 - 06/2009
3	Abdominal Obesity 06/2012 - 08/2007
2	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2018
2	Hypercholesterolemia 06/2012 - 04/2012
1	Weight Gain 01/2017
1	Hypersensitivity (Allergy) 01/2014
1	Thinness 01/2014
1	Overnutrition 03/2010
1	Inflammation (Inflammations) 12/2009
1	Fever (Fevers) 12/2009
1	Weight Loss (Weight Reduction) 12/2009
1	Anorexia 12/2009
1	Hyperglycemia 06/2009
1	Hyperplasia 08/2007
1	Diabetes Mellitus 10/2005
1	Pheochromocytoma 08/2005
1	Neoplasms (Cancer) 08/2005
1	Islet cell tumor syndrome 08/2005
1	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2004

Drug/Important Bio-Agent (IBA)

23	Insulin (Novolin)FDA Link 03/2021 - 02/2002
18	Glucose (Dextrose)FDA LinkGeneric 03/2021 - 02/2002
13	LipidsIBA 01/2018 - 01/2004
12	PKC-3 proteinIBA 03/2021 - 01/2004
9	EnzymesIBA 03/2021 - 06/2004
5	Triglycerides (Triacylglycerol)IBA 01/2011 - 06/2004
4	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2015 - 01/2004
4	Protein Kinases (Protein Kinase)IBA 07/2014 - 06/2004
4	Phosphotransferases (Kinase)IBA 06/2012 - 06/2009
3	Protein Kinase CIBA 01/2017 - 01/2004
3	LeptinIBA 01/2017 - 12/2009
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 06/2009 - 01/2004
3	protein kinase C lambdaIBA 06/2009 - 06/2004
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2015
2	Sterol Regulatory Element Binding Protein 1IBA 01/2018 - 06/2009
2	CeramidesIBA 11/2015 - 01/2015
2	Insulin ReceptorIBA 11/2015 - 01/2004
2	CarbohydratesIBA 04/2012 - 03/2010
2	Diacylglycerol O-AcyltransferaseIBA 07/2007 - 06/2004
2	Acyl Coenzyme A (Acyl CoA)IBA 07/2007 - 06/2004
2	protein kinase C zetaIBA 08/2003 - 10/2002
1	SodiumIBA 03/2021
1	AngiotensinsIBA 03/2021
1	ReninIBA 03/2021
1	Peptides (Polypeptides)IBA 01/2021
1	Amyloid (Amyloid Fibrils)IBA 01/2021
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018
1	MelanocortinsIBA 01/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 01/2017
1	TOR Serine-Threonine KinasesIBA 01/2015
1	PhosphoenolpyruvateIBA 01/2014
1	Gold Sodium Thiomalate (Sodium Aurothiomalate)IBA 04/2012
1	Nonesterified Fatty Acids (NEFA)IBA 01/2011
1	AdiponectinIBA 01/2011
1	PPAR-gamma AgonistsIBA 01/2011
1	Deoxyglucose (2 Deoxy D glucose)IBA 06/2010
1	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2009
1	LipopolysaccharidesIBA 12/2009
1	Hormones (Hormone)IBA 12/2009
1	EndotoxinsIBA 12/2009
1	CytokinesIBA 12/2009
1	NF-kappa B (NF-kB)IBA 06/2009
1	SterolsIBA 06/2009
1	ElementsIBA 06/2009
1	LDL CholesterolIBA 08/2007
1	HDL CholesterolIBA 08/2007
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 08/2007
1	CholesterolIBA 04/2006
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 08/2005
1	Nerve Growth Factor (NGF)IBA 08/2005
1	B-insulinIBA 06/2004
1	Insulin Receptor Substrate ProteinsIBA 06/2004
1	Serine (L-Serine)FDA Link 06/2004
1	Rosiglitazone (Avandia)FDA Link 08/2003

Therapy/Procedure

1	Therapeutics 10/2014